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mubashra.rauf28
mubashra.rauf28
Posts : 74
Join date : 2017-09-04
Age : 31
Location : Lahore Pakistan

CRISPR fix disease gene Empty CRISPR fix disease gene

Sun Sep 10, 2017 10:44 am
CRISPR-Cas9 gene editing technique has been used by researchers to make precise changes to genomes with relative ease so that those genes that cause mutation in viable embryos could be corrected. A mutation in gene known as MYBPC3 has been targeted, this mutation leads to hypertrophic cardiomyopathy, which is a leading cause of sudden death in young athletes. This is a dominant mutation case, so even a person inherit one copy of this gene from any parents, it will be expressed. Also, the risk of unwanted genetic changes and the risk of creating a mosaic (different genetic sequence in different cells of embryo), was also overcome. Studies regarding understanding the basic reproductive and developmental biology is still going on. The CRISPR system requires an enzyme called Cas9, that cut the genome at a site targeted by an RNA guided molecule. However, injecting the Cas9 protein itself, bounds to it's guide RNA, directly into the cells. This technique is used merely to correct disordered genes, not for creating designer babies.
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